Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression
نویسندگان
چکیده
منابع مشابه
Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells.
The development of human breast cancer is a complex multi-step process that depends on various exogenous and endogenous factors that modulate the transformation of normal human breast epithelial cells into neoplastic ones. Using a spontaneously-immortalized human breast epithelial (MCF-10F) cell line, we have shown previously that radiation, in combination with estrogen, induces a stepwise neop...
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BACKGROUND Breast cancer is a heterogeneous disease with various histological features and molecular markers. These are utilized for the prediction of clinical outcome and therapeutic decision making. In addition to well established markers such as HER2 overexpression and estrogen and progesterone receptor (ER and PR) status, chromosomal instability is evolving as an important hallmark of cance...
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Recent genome-wide associations studies (GWAS) have identified hundreds of common variants associated with the risk of developing breast cancer. However, a major challenge in the post-GWAS era is to understand the functional consequences of the identified SNPs. One of the main issues is that the majority of risk-associated SNPs fall in noncoding regions, and are predicted to function via cis-re...
متن کاملThe BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.
Frequent allelic loss at human chromosome 11q23-q24 occurs in a wide variety of cancers, suggesting that this region may harbor a tumor suppressor gene. By constructing a physical map of the LOH11CR2 minimal region of loss on 11q23-q24 associated with lung and breast carcinomas, we were able to clone a hereditary translocation, t(11;12)(q23;q24), in a patient with early-onset breast cancer and ...
متن کاملRoy 27_7
Multiple genetic alterations are common in cancers including those of the breast. The mechanisms leading to these alterations such as point mutations, gene amplifications, deletions and replication error are often associated with frequent and consistent loss of heterozygosity (LOH) or microsatellite instability (MSI). Several cytological and molecular studies have shown high frequency loss of g...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2006
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.28.3.667